Evaluation of smallpox vaccines using variola neutralization.
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ABSTRACT:
SUBMITTER: Damon IK
PROVIDER: S-EPMC2887573 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Publications
Evaluation of smallpox vaccines using variola neutralization.
Damon Inger K IK Davidson Whitni B WB Hughes Christine M CM Olson Victoria A VA Smith Scott K SK Holman Robert C RC Frey Sharon E SE Newman Frances F Belshe Robert B RB Yan Lihan L Karem Kevin K
The Journal of general virology 20090401 Pt 8
The search for a 'third'-generation smallpox vaccine has resulted in the development and characterization of several vaccine candidates. A significant barrier to acceptance is the absence of challenge models showing induction of correlates of protective immunity against variola virus. In this light, virus neutralization provides one of few experimental methods to show specific 'in vitro' activity of vaccines against variola virus. Here, we provide characterization of the ability of a modified va ...[more]
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