Ontology highlight
ABSTRACT:
SUBMITTER: He R
PROVIDER: S-EPMC2000444 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
He Rui R Oyoshi Michiko K MK Jin Haoli H Geha Raif S RS
Proceedings of the National Academy of Sciences of the United States of America 20070924 40
IL-17 has been implicated in a number of inflammatory diseases, but the conditions of antigen exposure that drive the generation of Th17 responses have not been well defined. Epicutaneous (EC) immunization of mice with ovalbumin (OVA), which causes allergic skin inflammation with many characteristics of the skin lesions of atopic dermatitis, was found to also drive IL-17 expression in the skin. EC, but not i.p., immunization of mice with OVA drove the generation of IL-17-producing T cells in dra ...[more]