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Performance of a whole-body human dust inhalation challenge exposure chamber.


ABSTRACT: Background:Evaluation of the performance of a whole-body human dust exposure chamber is presented in this report. Methods:The volume of the chamber is 2.13?m3 and it is operated at a flow rate of 1.0?m3/min. Makeup and exhaust air were filtered. A Wright Dust Feeder was used to generate fly ash, the testing agent. An elutriator was used to maintain particles in the respirable range. A Rupprecht and Patashnick PM-10 TEOM, a direct reading instrument, was used to monitor particle concentration. Particle size distributions were determined by a QCM cascade impactor. The evenness of dust concentrations in the chamber was determined gravimetrically. Results:Dust concentrations measured at different points within the chamber were associated with variability less than 10%. Dust concentrations measured by the TEOM, in ?g/m3, at 0.2, 0.4, 0.8 and 1.6 RPMs of the Wright Dust Feeder, were 110?±?2.8, 173?±?8.5, 398?±?20 and 550?±?17, respectively. Particle size distributions (MMD and GSD) were 1.27??m and 2.35, 1.39 and 2.22, 1.46 and 2.08, 1.15 and 2.2, respectively. Total dust concentrations measured gravimetrically in ?g/m3, were 135?±?21, 200?±?35, 333?±?18 and 891?±?27, respectively. Conclusion:The whole-body human exposure chamber offers several advantages and has better performance than most of the inhalation challenge systems previously described.

SUBMITTER: Pieretti LF 

PROVIDER: S-EPMC6086143 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Performance of a whole-body human dust inhalation challenge exposure chamber.

Pieretti Luis F LF   Hammad Yehia Y YY  

Toxicology reports 20180725


<h4>Background</h4>Evaluation of the performance of a whole-body human dust exposure chamber is presented in this report.<h4>Methods</h4>The volume of the chamber is 2.13 m<sup>3</sup> and it is operated at a flow rate of 1.0 m<sup>3</sup>/min. Makeup and exhaust air were filtered. A Wright Dust Feeder was used to generate fly ash, the testing agent. An elutriator was used to maintain particles in the respirable range. A Rupprecht and Patashnick PM-10 TEOM, a direct reading instrument, was used  ...[more]

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