Ontology highlight
ABSTRACT:
SUBMITTER: Hao HX
PROVIDER: S-EPMC2000499 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Hao Huai-Xiang HX Cardon Caleb M CM Swiatek Wojtek W Cooksey Robert C RC Smith Tammy L TL Wilde James J Boudina Sihem S Abel E Dale ED McClain Donald A DA Rutter Jared J
Proceedings of the National Academy of Sciences of the United States of America 20070918 39
The metabolic syndrome, a complex set of phenotypes typically associated with obesity and diabetes, is an increasing threat to global public health. Fundamentally, the metabolic syndrome is caused by a failure to properly sense and respond to cellular metabolic cues. We studied the role of the cellular metabolic sensor PAS kinase (PASK) in the pathogenesis of metabolic disease by using PASK(-/-) mice. We identified tissue-specific metabolic phenotypes caused by PASK deletion consistent with its ...[more]