Ontology highlight
ABSTRACT:
SUBMITTER: Garcia D
PROVIDER: S-EPMC5553560 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Garcia Daniel D Shaw Reuben J RJ
Molecular cell 20170601 6
AMPK is a highly conserved master regulator of metabolism, which restores energy balance during metabolic stress both at the cellular and physiological levels. The identification of numerous AMPK targets has helped explain how AMPK restores energy homeostasis. Recent advancements illustrate novel mechanisms of AMPK regulation, including changes in subcellular localization and phosphorylation by non-canonical upstream kinases. Notably, the therapeutic potential of AMPK is widely recognized and he ...[more]