Ontology highlight
ABSTRACT:
SUBMITTER: Giardina SF
PROVIDER: S-EPMC2001300 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Giardina Sarah F SF Mikami Maya M Goubaeva Farida F Yang Jay J
Biochemical and biophysical research communications 20070822 3
The current study aimed to understand the anti-apoptotic effect of overexpressed gap junction forming protein connexin (Cx) 43 in C6 glioma cells. C6 cells exposed to hydrogen peroxide (H2O2) or staurosporine demonstrated morphological and biochemical changes consistent with apoptosis, whereas C6 cells expressing Cx43 demonstrated relative resistance to H2O2, but not to staurosporine. This selective protection against H2O2 was due to inhibition of caspase-3 activation in Cx43 expressing cells. s ...[more]