Ontology highlight
ABSTRACT:
SUBMITTER: Dzikowski R
PROVIDER: S-EPMC2002552 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Dzikowski Ron R Li Felomena F Amulic Borko B Eisberg Andrew A Frank Matthias M Patel Suchit S Wellems Thomas E TE Deitsch Kirk W KW
EMBO reports 20070831 10
A fundamental yet poorly understood aspect of gene regulation in eukaryotic organisms is the mechanisms that control allelic exclusion and mutually exclusive gene expression. In the malaria parasite Plasmodium falciparum, this process regulates expression of the var gene family--a large, hypervariable repertoire of genes that are responsible for the ability of the parasite to evade the host immune system and for pathogenesis of the disease. A central problem in understanding this process concern ...[more]