Ontology highlight
ABSTRACT:
SUBMITTER: De Niz M
PROVIDER: S-EPMC4894950 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
De Niz Mariana M Ullrich Ann-Katrin AK Heiber Arlett A Blancke Soares Alexandra A Pick Christian C Lyck Ruth R Keller Derya D Kaiser Gesine G Prado Monica M Flemming Sven S Del Portillo Hernando H Janse Chris J CJ Heussler Volker V Spielmann Tobias T
Nature communications 20160526
Sequestration of red blood cells infected with the human malaria parasite Plasmodium falciparum in organs such as the brain is considered important for pathogenicity. A similar phenomenon has been observed in mouse models of malaria, using the rodent parasite Plasmodium berghei, but it is unclear whether the P. falciparum proteins known to be involved in this process are conserved in the rodent parasite. Here we identify the P. berghei orthologues of two such key factors of P. falciparum, SBP1 a ...[more]