Ontology highlight
ABSTRACT:
SUBMITTER: Morrison BH
PROVIDER: S-EPMC2025680 | biostudies-literature | 2001 Jul
REPOSITORIES: biostudies-literature
Morrison B H BH Bauer J A JA Kalvakolanu D V DV Lindner D J DJ
The Journal of biological chemistry 20010503 27
Interferons (IFNs) regulate the expression of genes that mediate their antiviral, antitumor, and immunomodulatory actions. We have previously shown that IFN-beta suppresses growth of human ovarian carcinoma xenografts in vivo and induces apoptosis of ovarian carcinoma cells in vitro. To investigate mechanisms of IFN-beta-induced apoptosis we employed an antisense technical knockout approach to identify gene products that mediate cell death and have isolated several regulators of interferon-induc ...[more]