Ontology highlight
ABSTRACT:
SUBMITTER: Qiu X
PROVIDER: S-EPMC20290 | biostudies-literature | 1997 Apr
REPOSITORIES: biostudies-literature
Qiu X X Janson C A CA Culp J S JS Richardson S B SB Debouck C C Smith W W WW Abdel-Meguid S S SS
Proceedings of the National Academy of Sciences of the United States of America 19970401 7
Varicella-zoster virus (VZV), an alpha-herpes virus, is the causative agent of chickenpox, shingles, and postherpetic neuralgia. The three-dimensional crystal structure of the serine protease from VZV has been determined at 3.0-A resolution. The VZV protease is essential for the life cycle of the virus and is a potential target for therapeutic intervention. The structure reveals an overall fold that is similar to that recently reported for the serine protease from cytomegalovirus (CMV), a herpes ...[more]