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Decreased expression of beta1- and beta2-adrenoceptors in human diabetic atrial appendage.


ABSTRACT: BACKGROUND: Using the streptozotocin-induced diabetic rat model, we have recently showed that the expression and function of beta1-adrenoreceptor were decreased in the diabetic rat heart. However, the effect of diabetes on expression of beta-adrenoreceptors in human cardiac tissue remains undefined. Therefore, the focus of the present study was to investigate the effect of diabetes on mRNA encoding beta1- and beta2-ARs in human atrial tissues. METHODS: Right atrial appendages from five diabetic (mean age 65 +/- 4.5; 4 female, 1 male) and five nondiabetic patients (mean age 56.2 +/- 2.8; 4 male, 1 female) undergoing coronary artery bypass grafting were collected and assayed using reverse transcriptase-polymerase chain reaction (RT-PCR) for their mRNA content. No patient from these two groups suffered from acute myocardial infarction and/or failure. All diabetic patients received insulin for at least two years and had been diagnosed as diabetics for at least five years. RESULTS: When compared with levels in nondiabetics, steady state levels of mRNA encoding beta1-adrenoreceptor decreased by 69.2 +/- 7.6% in diabetic patients while beta2-adrenoreceptor mRNA decreased by 32.2 +/- 5.5% (p < 0.001). CONCLUSIONS: Our findings show a decreased expression of beta1- and beta2-adrenoreceptors in human diabetic atrial appendage.

SUBMITTER: Dincer UD 

PROVIDER: S-EPMC203305 | biostudies-literature | 2003 Jun

REPOSITORIES: biostudies-literature

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Decreased expression of beta1- and beta2-adrenoceptors in human diabetic atrial appendage.

Dinçer U Deniz UD   Güner Sahika S   Tay Aydin A   Arioğlu Ebru E   Taşdelen Atilay A   Aşlamaci Sait S   Bidasee Keshore R KR  

Cardiovascular diabetology 20030620


<h4>Background</h4>Using the streptozotocin-induced diabetic rat model, we have recently showed that the expression and function of beta1-adrenoreceptor were decreased in the diabetic rat heart. However, the effect of diabetes on expression of beta-adrenoreceptors in human cardiac tissue remains undefined. Therefore, the focus of the present study was to investigate the effect of diabetes on mRNA encoding beta1- and beta2-ARs in human atrial tissues.<h4>Methods</h4>Right atrial appendages from f  ...[more]

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