Ontology highlight
ABSTRACT:
SUBMITTER: Oh SD
PROVIDER: S-EPMC2034285 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Oh Steve D SD Lao Jessica P JP Hwang Patty Yi-Hwa PY Taylor Andrew F AF Smith Gerald R GR Hunter Neil N
Cell 20070701 2
Bloom's helicase (BLM) is thought to prevent crossing-over during DNA double-strand-break repair (DSBR) by disassembling double-Holliday junctions (dHJs) or by preventing their formation. We show that the Saccharomyces cerevisiae BLM ortholog, Sgs1, prevents aberrant crossing-over during meiosis by suppressing formation of joint molecules (JMs) comprising three and four interconnected duplexes. Sgs1 and procrossover factors, Msh5 and Mlh3, are antagonistic since Sgs1 prevents dHJ formation in ms ...[more]