Ontology highlight
ABSTRACT:
SUBMITTER: She M
PROVIDER: S-EPMC2040073 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
She Meipei M Decker Carolyn J CJ Sundramurthy Kumar K Liu Yuying Y Chen Nan N Parker Roy R Song Haiwei H
Nature structural & molecular biology 20040201 3
A major pathway of eukaryotic mRNA turnover begins with deadenylation, followed by decapping and 5'-->3' exonucleolytic degradation. A critical step in this pathway is decapping, which is carried out by an enzyme composed of Dcp1p and Dcp2p. The crystal structure of Dcp1p shows that it markedly resembles the EVH1 family of protein domains. Comparison of the proline-rich sequence (PRS)-binding sites in this family of proteins with Dcp1p indicates that it belongs to a novel class of EVH1 domains. ...[more]