Ontology highlight
ABSTRACT:
SUBMITTER: Ling SH
PROVIDER: S-EPMC2547010 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20080804 19
Edc3 is an enhancer of decapping and serves as a scaffold that aggregates mRNA ribonucleoproteins together for P-body formation. Edc3 forms a network of interactions with the components of the mRNA decapping machinery and has a modular domain architecture consisting of an N-terminal Lsm domain, a central FDF domain, and a C-terminal YjeF-N domain. We have determined the crystal structure of the N-terminally truncated human Edc3 at a resolution of 2.2 A. The structure reveals that the YjeF-N doma ...[more]