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Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells.

ABSTRACT: We explored the physiological role of conventional dendritic cells (cDCs) in acute colitis induced by a single cycle of dextran sodium sulfate administration. Depending on their mode of activation and independently of T cells, cDCs can enhance or attenuate the severity of dextran sodium sulfate-induced colitis. The latter beneficial effect was achieved, in part, by IFN-1 induced by Toll-like receptor 9-activated cDCs. IFN-1 inhibits colonic inflammation by regulating neutrophil and monocyte trafficking to the inflamed colon and restraining the inflammatory products of tissue macrophages. These data highlight a novel role of cDCs in the regulation of other innate immune cells and position them as major players in acute colonic inflammation.

SUBMITTER: Abe K

PROVIDER: S-EPMC2040469 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature

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Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells.

Abe Kazumichi K Nguyen Kim Phung KP Fine Sean D SD Mo Ji-Hun JH Shen Carol C Shenouda Steve S Corr Maripat M Jung Steffen S Lee Jongdae J Eckmann Lars L Raz Eyal E

Proceedings of the National Academy of Sciences of the United States of America 20071017 43

We explored the physiological role of conventional dendritic cells (cDCs) in acute colitis induced by a single cycle of dextran sodium sulfate administration. Depending on their mode of activation and independently of T cells, cDCs can enhance or attenuate the severity of dextran sodium sulfate-induced colitis. The latter beneficial effect was achieved, in part, by IFN-1 induced by Toll-like receptor 9-activated cDCs. IFN-1 inhibits colonic inflammation by regulating neutrophil and monocyte traf ...[more]

PMID: 17942668

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