Ontology highlight
ABSTRACT:
SUBMITTER: Bandyopadhyay BC
PROVIDER: S-EPMC3004519 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Journal of leukocyte biology 20101022 1
SOCE via CRAC channels is a critical signaling event in immune cells. Recent studies have identified key proteins underlying this process; STIM is an ER Ca²+ sensor that interacts with Orai, an intrinsic, pore-forming protein of the CRAC channel. In heterologous expression systems, STIM1 regulates SOCE by interacting with Orai1, -2, and -3. In native tissues, however, the precise roles of STIM and Orai proteins are not well defined. Here, we have investigated the molecular components of SOCE sig ...[more]