Ontology highlight
ABSTRACT:
SUBMITTER: Remy S
PROVIDER: S-EPMC2040482 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Remy Stefan S Spruston Nelson N
Proceedings of the National Academy of Sciences of the United States of America 20071016 43
The hippocampus is essential for episodic memory, which requires single-trial learning. Although long-term potentiation (LTP) of synaptic strength is a candidate mechanism for learning, it is typically induced by using repeated synaptic activation to produce precisely timed, high-frequency, or rhythmic firing. Here we show that hippocampal synapses potentiate robustly in response to strong activation by a single burst. The induction mechanism of this single-burst LTP requires activation of NMDA ...[more]