Ontology highlight
ABSTRACT:
SUBMITTER: Kim S
PROVIDER: S-EPMC5896953 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Kim Sooyun S Kim Yoonsub Y Lee Suk-Ho SH Ho Won-Kyung WK
eLife 20180326
Long-term potentiation (LTP) of synaptic responses is essential for hippocampal memory function. Perforant-path (PP) synapses on hippocampal granule cells (GCs) contribute to the formation of associative memories, which are considered the cellular correlates of memory engrams. However, the mechanisms of LTP at these synapses are not well understood. Due to sparse firing activity and the voltage attenuation in their dendrites, it remains unclear how associative LTP at distal synapses occurs. Here ...[more]