Ontology highlight
ABSTRACT:
SUBMITTER: Manzo A
PROVIDER: S-EPMC2043516 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Manzo Antonio A Bugatti Serena S Caporali Roberto R Prevo Remko R Jackson David G DG Uguccioni Mariagrazia M Buckley Christopher D CD Montecucco Carlomaurizio C Pitzalis Costantino C
The American journal of pathology 20071101 5
CCL21 is a homeostatic lymphoid chemokine instrumental in the recruitment and organization of T cells and dendritic cells into lymphoid T areas. In human secondary lymphoid organs (SLOs), CCL21 is produced by cells distributed throughout the T zone, whereas high endothelial venules (HEVs) lack CCL21 mRNA. A critical question remains whether the development of ectopic lymphoid tissue (ELT) in chronic inflammation recapitulates the features of SLOs. Thus, we systematically investigated in situ the ...[more]