Ontology highlight
ABSTRACT:
SUBMITTER: Bazzaro M
PROVIDER: S-EPMC2043524 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Bazzaro Martina M Santillan Antonio A Lin Zhenhua Z Tang Taylor T Lee Michael K MK Bristow Robert E RE Shih Ie-Ming IeM Roden Richard B S RB
The American journal of pathology 20070914 5
Both tumor cell proliferation and metastasis are dependent on myosin II. Because UNC-45 is required to chaperone the assembly of a functional myosin II motor, we examined the expression of the general cell (GC) UNC-45 isoform in ovarian tumors. Serous carcinoma expressed elevated levels of GC UNC-45 compared with normal ovarian surface epithelium and benign cystadenoma. High-stage exhibited greater GC UNC-45 expression than low-stage serous carcinoma. Similarly, GC UNC-45 transcripts and protein ...[more]