Ontology highlight
ABSTRACT:
SUBMITTER: Lee CF
PROVIDER: S-EPMC3060410 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Lee Chi F CF Hauenstein Arthur V AV Fleming Jonathan K JK Gasper William C WC Engelke Valerie V Sankaran Banumathi B Bernstein Sanford I SI Huxford Tom T
Structure (London, England : 1993) 20110301 3
UCS proteins, such as UNC-45, influence muscle contraction and other myosin-dependent motile processes. We report the first X-ray crystal structure of a UCS domain-containing protein, the UNC-45 myosin chaperone from Drosophila melanogaster (DmUNC-45). The structure reveals that the central and UCS domains form a contiguous arrangement of 17 consecutive helical layers that arrange themselves into five discrete armadillo repeat subdomains. Small-angle X-ray scattering data suggest that free DmUNC ...[more]