Unknown

Dataset Information

0

Islands of euchromatin-like sequence and expressed polymorphic sequences within the short arm of human chromosome 21.

ABSTRACT: The goals of the human genome project did not include sequencing of the heterochromatic regions. We describe here an initial sequence of 1.1 Mb of the short arm of human chromosome 21 (HSA21p), estimated to be 10% of 21p. This region contains extensive euchromatic-like sequence and includes on average one transcript every 100 kb. These transcripts show multiple inter- and intrachromosomal copies, and extensive copy number and sequence variability. The sequencing of the "heterochromatic" regions of the human genome is likely to reveal many additional functional elements and provide important evolutionary information.

SUBMITTER: Lyle R 

PROVIDER: S-EPMC2045151 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The goals of the human genome project did not include sequencing of the heterochromatic regions. We describe here an initial sequence of 1.1 Mb of the short arm of human chromosome 21 (HSA21p), estimated to be 10% of 21p. This region contains extensive euchromatic-like sequence and includes on average one transcript every 100 kb. These transcripts show multiple inter- and intrachromosomal copies, and extensive copy number and sequence variability. The sequencing of the "heterochromatic" regions  ...[more]

Similar Datasets

Unknown Mapping of the juxtacentromeric heterochromatin-euchromatin frontier of human chromosome 21.
| S-EPMC1581429 | biostudies-literature
Unknown High occurrence of functional new chimeric genes in survey of rice chromosome 3 short arm genome sequences.
| S-EPMC3673630 | biostudies-literature
Genomics High-resolution custom array spanning short arm of chromosome 17
2014-11-01 | GSE62004 | GEO
Unknown Recombination between the mouse Y chromosome short arm and an additional Y short arm-derived chromosomal segment attached distal to the X chromosome PAR.
| S-EPMC4830887 | biostudies-literature
Unknown A physical map of the short arm of wheat chromosome 1A.
| S-EPMC3836966 | biostudies-literature
Unknown Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin.
| S-EPMC7147806 | biostudies-literature
Unknown Clinical outcomes of fetuses with chromosome 16 short arm copy number variants.
| S-EPMC10337270 | biostudies-literature
Unknown Identification of human chromosome 22 transcribed sequences with ORF expressed sequence tags.
| S-EPMC18825 | biostudies-literature
Other Chromosome arm length, and a species-specific determinant, define chromosome arm width
2023-07-04 | GSE148307 | GEO
Unknown Genomic profile of copy number variants on the short arm of human chromosome 8.
| S-EPMC2987457 | biostudies-literature