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Sequential linezolid-resistant Staphylococcus epidermidis isolates with G2576T mutation.

ABSTRACT: We report on an analysis of sequential isolates of Staphylococcus epidermidis from cultures of blood obtained from a patient with acute myeloid leukemia while the patient was receiving linezolid treatment. All 12 isolates had a linezolid MIC of 32 microg/ml. A 420-bp domain V region of the 23S rRNA gene from all isolates was amplified, and their nucleotide sequences were determined. A G2576T mutation was identified in all isolates. It was estimated that 67% of the 23S rRNA genes carried this mutation. This is the first report of the failure of linezolid treatment for Staphylococcus epidermidis bacteremia associated with a G2576T mutation in an immunocompromised patient.

SUBMITTER: Hong T

PROVIDER: S-EPMC2045370 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature

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Sequential linezolid-resistant Staphylococcus epidermidis isolates with G2576T mutation.

Hong Tao T Li Xiangyang X Wang Jie J Sloan Cynthia C Cicogna Cristina C

Journal of clinical microbiology 20070801 10

We report on an analysis of sequential isolates of Staphylococcus epidermidis from cultures of blood obtained from a patient with acute myeloid leukemia while the patient was receiving linezolid treatment. All 12 isolates had a linezolid MIC of 32 microg/ml. A 420-bp domain V region of the 23S rRNA gene from all isolates was amplified, and their nucleotide sequences were determined. A G2576T mutation was identified in all isolates. It was estimated that 67% of the 23S rRNA genes carried this mut ...[more]

PMID: 17670931

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