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Linezolid dependence in Staphylococcus epidermidis bloodstream isolates.

ABSTRACT: We document linezolid dependence among 5 highly linezolid-resistant (LRSE) Staphylococcus epidermidis bloodstream isolates that grew substantially faster at 32 µg/mL linezolid presence. These isolates carried the mutations T2504A and C2534T in multiple 23S rRNA copies and 2 mutations leading to relevant amino acid substitutions in L3 protein. Linezolid dependence could account for increasing LRSE emergence.

SUBMITTER: Pournaras S

PROVIDER: S-EPMC3557967 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Linezolid dependence in Staphylococcus epidermidis bloodstream isolates.

Pournaras Spyros S Ntokou Eleni E Zarkotou Olympia O Ranellou Kyriaki K Themeli-Digalaki Katerina K Stathopoulos Constantinos C Tsakris Athanassios A

Emerging infectious diseases 20130101 1

We document linezolid dependence among 5 highly linezolid-resistant (LRSE) Staphylococcus epidermidis bloodstream isolates that grew substantially faster at 32 µg/mL linezolid presence. These isolates carried the mutations T2504A and C2534T in multiple 23S rRNA copies and 2 mutations leading to relevant amino acid substitutions in L3 protein. Linezolid dependence could account for increasing LRSE emergence. ...[more]

PMID: 23260390

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