Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC2048754 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Wang Ling L Dutta Shamit K SK Kojima Tatsuyoshi T Xu Xiaolei X Khosravi-Far Roya R Ekker Stephen C SC Mukhopadhyay Debabrata D
PloS one 20071114 11
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF), one of the crucial pro-angiogenic factors, functions as a potent inhibitor of endothelial cell (EC) apoptosis. Previous progress has been made towards delineating the VPF/VEGF survival signaling downstream of the activation of VEGFR-2. Here, we seek to define the function of NRP-1 in VPF/VEGF-induced survival signaling in EC and to elucidate the concomitant molecular signaling events that are pivotal for our understandin ...[more]