Ontology highlight
ABSTRACT:
SUBMITTER: Yu Z
PROVIDER: S-EPMC5158050 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Yu Zhixian Z Mouillesseaux Kevin P KP Kushner Erich J EJ Bautch Victoria L VL
PloS one 20161215 12
Approximately 30% of tumor endothelial cells have over-duplicated (>2) centrosomes, which may contribute to abnormal vessel function and drug resistance. Elevated levels of vascular endothelial growth factor A induce excess centrosomes in endothelial cells, but how other features of the tumor environment affect centrosome over-duplication is not known. To test this, we treated endothelial cells with tumor-derived factors, hypoxia, or reduced p53, and assessed centrosome numbers. We found that hy ...[more]