Ontology highlight
ABSTRACT:
SUBMITTER: Pan L
PROVIDER: S-EPMC2063473 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Pan Lifeng L Wu Hao H Shen Chong C Shi Yawei Y Jin Wenying W Xia Jun J Zhang Mingjie M
The EMBO journal 20071004 21
Protein interacting with c kinase 1 (PICK1) regulates the trafficking of receptors and ion-channels such as AMPA receptors. Traditionally, the PICK1 PDZ domain is regarded as an adaptor capable of binding to receptors trafficked by PICK1, and the lipid-binding BAR domain functions to tether PICK1 directly to membranes. Here, we show that the PICK1 PDZ domain can directly interact with lipid membranes. The PDZ domain and lipid membrane interaction is mediated by both a polybasic amino-acid cluste ...[more]