Ontology highlight
ABSTRACT:
SUBMITTER: Ng DC
PROVIDER: S-EPMC2063554 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Ng Dominic Chi Hiung DC Lin Bao Hong BH Lim Cheh Peng CP Huang Guochang G Zhang Tong T Poli Valeria V Cao Xinmin X
The Journal of cell biology 20060109 2
Stat3 is a member of the signal transducer and activator of transcription family, which is important in cytokine signaling. Gene ablation studies have revealed a requirement for Stat3 in diverse biological processes (Akira, S. 2000. Oncogene. 19: 2607-2611; Levy, D.E., and C.K. Lee. 2002. J. Clin. Invest. 109:1143-1148). Previously, the function of Stat3 had been attributed exclusively to its transcriptional activity in the nucleus. In this study, we reveal an interaction between Stat3 and the m ...[more]