Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1.
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ABSTRACT:
SUBMITTER: Morris EJ
PROVIDER: S-EPMC5424153 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1.
Morris Edward J EJ Kawamura Eiko E Gillespie Jordan A JA Balgi Aruna A Kannan Nagarajan N Muller William J WJ Roberge Michel M Dedhar Shoukat S
Nature communications 20170505
Cancer cells frequently have amplified centrosomes that must be clustered together to form a bipolar mitotic spindle, and targeting centrosome clustering is considered a promising therapeutic strategy. A high-content chemical screen for inhibitors of centrosome clustering identified Stattic, a Stat3 inhibitor. Stat3 depletion and inhibition in cancer cell lines and in tumours in vivo caused significant inhibition of centrosome clustering and viability. Here we describe a transcription-independen ...[more]
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