Ontology highlight
ABSTRACT:
SUBMITTER: Al-Bassam J
PROVIDER: S-EPMC2063759 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Al-Bassam Jawdat J van Breugel Mark M Harrison Stephen C SC Hyman Anthony A
The Journal of cell biology 20060301 7
Stu2p from budding yeast belongs to the conserved Dis1/XMAP215 family of microtubule-associated proteins (MAPs). The common feature of proteins in this family is the presence of HEAT repeat-containing TOG domains near the NH2 terminus. We have investigated the functions of the two TOG domains of Stu2p in vivo and in vitro. Our data suggest that Stu2p regulates microtubule dynamics through two separate activities. First, Stu2p binds to a single free tubulin heterodimer through its first TOG domai ...[more]