Ontology highlight
ABSTRACT:
SUBMITTER: Rezniczek GA
PROVIDER: S-EPMC2064082 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Rezniczek Günther A GA Konieczny Patryk P Nikolic Branislav B Reipert Siegfried S Schneller Doris D Abrahamsberg Christina C Davies Kay E KE Winder Steve J SJ Wiche Gerhard G
The Journal of cell biology 20070301 7
In skeletal muscle, the cytolinker plectin is prominently expressed at Z-disks and the sarcolemma. Alternative splicing of plectin transcripts gives rise to more than eight protein isoforms differing only in small N-terminal sequences (5-180 residues), four of which (plectins 1, 1b, 1d, and 1f) are found at substantial levels in muscle tissue. Using plectin isoform-specific antibodies and isoform expression constructs, we show the differential regulation of plectin isoforms during myotube differ ...[more]