Ontology highlight
ABSTRACT:
SUBMITTER: Dzhashiashvili Y
PROVIDER: S-EPMC2064285 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Dzhashiashvili Yulia Y Zhang Yanqing Y Galinska Jolanta J Lam Isabel I Grumet Martin M Salzer James L JL
The Journal of cell biology 20070601 5
Axon initial segments (AISs) and nodes of Ranvier are sites of action potential generation and propagation, respectively. Both domains are enriched in sodium channels complexed with adhesion molecules (neurofascin [NF] 186 and NrCAM) and cytoskeletal proteins (ankyrin G and betaIV spectrin). We show that the AIS and peripheral nervous system (PNS) nodes both require ankyrin G but assemble by distinct mechanisms. The AIS is intrinsically specified; it forms independent of NF186, which is targeted ...[more]