Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC3448493 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Zhang Yanqing Y Bekku Yoko Y Dzhashiashvili Yulia Y Armenti Stephen S Meng Xiaosong X Sasaki Yo Y Milbrandt Jeffrey J Salzer James L JL
Neuron 20120101 1
<h4>Video abstract</h4>We have investigated the source(s) and targeting of components to PNS nodes of Ranvier. We show adhesion molecules are freely diffusible within the axon membrane and accumulate at forming nodes from local sources, whereas ion channels and cytoskeletal components are largely immobile and require transport to the node. We further characterize targeting of NF186, an adhesion molecule that pioneers node formation. NF186 redistributes to nascent nodes from a mobile, surface poo ...[more]