Ontology highlight
ABSTRACT:
SUBMITTER: Kunisaki Y
PROVIDER: S-EPMC2064308 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Kunisaki Yuya Y Nishikimi Akihiko A Tanaka Yoshihiko Y Takii Ryosuke R Noda Mayuko M Inayoshi Ayumi A Watanabe Ken-ichi K Sanematsu Fumiyuki F Sasazuki Takehiko T Sasaki Takehiko T Fukui Yoshinori Y
The Journal of cell biology 20060801 5
Neutrophils are highly motile leukocytes, and they play important roles in the innate immune response to invading pathogens. Neutrophil chemotaxis requires Rac activation, yet the Rac activators functioning downstream of chemoattractant receptors remain to be determined. We show that DOCK2, which is a mammalian homologue of Caenorhabditis elegans CED-5 and Drosophila melanogaster Myoblast City, regulates motility and polarity during neutrophil chemotaxis. Although DOCK2-deficient neutrophils mov ...[more]