Ontology highlight
ABSTRACT:
SUBMITTER: Yin VP
PROVIDER: S-EPMC2064425 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
The Journal of cell biology 20070625 1
A pulse of the steroid hormone ecdysone triggers the destruction of larval salivary glands during Drosophila metamorphosis through a transcriptional cascade that converges on reaper (rpr) and head involution defective (hid) induction, resulting in caspase activation and cell death. We identify the CREB binding protein (CBP) transcriptional cofactor as essential for salivary gland cell death. We show that CBP acts 1 d before the onset of metamorphosis in apparent response to a mid-third instar ec ...[more]