Ontology highlight
ABSTRACT:
SUBMITTER: Tian L
PROVIDER: S-EPMC2064474 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Tian Li L Stefanidakis Michael M Ning Lin L Van Lint Philippe P Nyman-Huttunen Henrietta H Libert Claude C Itohara Shigeyoshi S Mishina Masayoshi M Rauvala Heikki H Gahmberg Carl G CG
The Journal of cell biology 20070806 4
Matrix metalloproteinase (MMP)-2 and -9 are pivotal in remodeling many tissues. However, their functions and candidate substrates for brain development are poorly characterized. Intercellular adhesion molecule-5 (ICAM-5; Telencephalin) is a neuronal adhesion molecule that regulates dendritic elongation and spine maturation. We find that ICAM-5 is cleaved from hippocampal neurons when the cells are treated with N-methyl-d-aspartic acid (NMDA) or alpha-amino-3-hydroxy-5-methylisoxazole-propionic a ...[more]