Ontology highlight
ABSTRACT:
SUBMITTER: Comrie WA
PROVIDER: S-EPMC4332244 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Comrie William A WA Li Shuixing S Boyle Sarah S Burkhardt Janis K JK
The Journal of cell biology 20150209 4
Integrity of the dendritic cell (DC) actin cytoskeleton is essential for T cell priming, but the underlying mechanisms are poorly understood. We show that the DC F-actin network regulates the lateral mobility of intracellular cell adhesion molecule 1 (ICAM-1), but not MHCII. ICAM-1 mobility and clustering are regulated by maturation-induced changes in the expression and activation of moesin and α-actinin-1, which associate with actin filaments and the ICAM-1 cytoplasmic domain. Constrained ICAM- ...[more]