Ontology highlight
ABSTRACT:
SUBMITTER: Liu Q
PROVIDER: S-EPMC2064544 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Liu Qian Q Pante Nelly N Misteli Tom T Elsagga Mohamed M Crisp Melissa M Hodzic Didier D Burke Brian B Roux Kyle J KJ
The Journal of cell biology 20070801 5
Sun1 and 2 are A-type lamin-binding proteins that, in association with nesprins, form a link between the inner nuclear membranes (INMs) and outer nuclear membranes of mammalian nuclear envelopes. Both immunofluorescence and immunoelectron microscopy reveal that Sun1 but not Sun2 is intimately associated with nuclear pore complexes (NPCs). Topological analyses indicate that Sun1 is a type II integral protein of the INM. Localization of Sun1 to the INM is defined by at least two discrete regions w ...[more]