Ontology highlight
ABSTRACT:
SUBMITTER: Santhosh U
PROVIDER: S-EPMC206456 | biostudies-literature | 2003 Oct
REPOSITORIES: biostudies-literature
Santhosh U U Schuster Gary B GB
Nucleic acids research 20031001 19
DNA three-way junctions (TWJ) are branched molecules having three 'arms'. We studied long-distance radical cation migration in these assemblies by incorporating anthraquinone (AQ) groups linked by a covalent tether to one strand of one arm of the TWJ. Excitation of the AQ at 350 nm results in one-electron oxidation of the DNA, which generates a base radical cation. This leads to relatively inefficient (compared with duplex DNA) strand cleavage at guanines following piperidine treatment of the ir ...[more]