Ontology highlight
ABSTRACT:
SUBMITTER: Terry LJ
PROVIDER: S-EPMC2064648 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Terry Laura J LJ Wente Susan R SR
The Journal of cell biology 20070917 7
Trafficking of nucleic acids and large proteins through nuclear pore complexes (NPCs) requires interactions with NPC proteins that harbor FG (phenylalanine-glycine) repeat domains. Specialized transport receptors that recognize cargo and bind FG domains facilitate these interactions. Whether different transport receptors utilize preferential FG domains in intact NPCs is not fully resolved. In this study, we use a large-scale deletion strategy in Saccharomyces cerevisiae to generate a new set of ...[more]