Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez-Martinez J
PROVIDER: S-EPMC5130164 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Fernandez-Martinez Javier J Kim Seung Joong SJ Shi Yi Y Upla Paula P Pellarin Riccardo R Gagnon Michael M Chemmama Ilan E IE Wang Junjie J Nudelman Ilona I Zhang Wenzhu W Williams Rosemary R Rice William J WJ Stokes David L DL Zenklusen Daniel D Chait Brian T BT Sali Andrej A Rout Michael P MP
Cell 20161110 5
The last steps in mRNA export and remodeling are performed by the Nup82 complex, a large conserved assembly at the cytoplasmic face of the nuclear pore complex (NPC). By integrating diverse structural data, we have determined the molecular architecture of the native Nup82 complex at subnanometer precision. The complex consists of two compositionally identical multiprotein subunits that adopt different configurations. The Nup82 complex fits into the NPC through the outer ring Nup84 complex. Our m ...[more]