Ontology highlight
ABSTRACT:
SUBMITTER: Nickerson DP
PROVIDER: S-EPMC2064671 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Nickerson Daniel P DP West Matthew M Odorizzi Greg G
The Journal of cell biology 20061127 5
The sorting of transmembrane cargo proteins into the lumenal vesicles of multivesicular bodies (MVBs) depends on the recruitment of endosomal sorting complexes required for transport (ESCRTs) to the cytosolic face of endosomal membranes. The subsequent dissociation of ESCRT complexes from endosomes requires Vps4, a member of the AAA family of adenosine triphosphatases. We show that Did2 directs Vps4 activity to the dissociation of ESCRT-III but has no role in the dissociation of ESCRT-I or -II. ...[more]