Ontology highlight
ABSTRACT:
SUBMITTER: Schramm VL
PROVIDER: S-EPMC2066183 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Current opinion in chemical biology 20070914 5
Kinetic isotope effects are increasingly applied to investigate enzyme reactions and have been used to understand transition state structure, reaction mechanisms, quantum mechanical hydride ion tunneling and to design transition state analogue inhibitors. Binding isotope effects are an inherent part of most isotope effect measurements but are usually assumed to be negligible. More detailed studies have established surprisingly large binding isotope effects with lactate dehydrogenase, hexokinase, ...[more]