Ontology highlight
ABSTRACT:
SUBMITTER: Limbo O
PROVIDER: S-EPMC2066204 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Limbo Oliver O Chahwan Charly C Yamada Yoshiki Y de Bruin Robertus A M RA Wittenberg Curt C Russell Paul P
Molecular cell 20071001 1
The Mre11-Rad50-Nbs1 (MRN) complex is a primary sensor of DNA double-strand breaks (DSBs). Upon recruitment to DSBs, it plays a critical role in catalyzing 5' --> 3' single-strand resection that is required for repair by homologous recombination (HR). Unknown mechanisms repress HR in G1 phase of the cell cycle during which nonhomologous end-joining (NHEJ) is the favored mode of DSB repair. Here we describe fission yeast Ctp1, so-named because it shares conserved domains with the mammalian tumor ...[more]