Ontology highlight
ABSTRACT:
SUBMITTER: Rota M
PROVIDER: S-EPMC2077031 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Rota Marcello M Kajstura Jan J Hosoda Toru T Bearzi Claudia C Vitale Serena S Esposito Grazia G Iaffaldano Grazia G Padin-Iruegas M Elena ME Gonzalez Arantxa A Rizzi Roberto R Small Narissa N Muraski John J Alvarez Roberto R Chen Xiongwen X Urbanek Konrad K Bolli Roberto R Houser Steven R SR Leri Annarosa A Sussman Mark A MA Anversa Piero P
Proceedings of the National Academy of Sciences of the United States of America 20071026 45
The possibility that adult bone marrow cells (BMCs) retain a remarkable degree of developmental plasticity and acquire the cardiomyocyte lineage after infarction has been challenged, and the notion of BMC transdifferentiation has been questioned. The center of the controversy is the lack of unequivocal evidence in favor of myocardial regeneration by the injection of BMCs in the infarcted heart. Because of the interest in cell-based therapy for heart failure, several approaches including gene rep ...[more]