Ontology highlight
ABSTRACT:
SUBMITTER: Cain CD
PROVIDER: S-EPMC2077034 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Cain Christopher D CD Schroeder Frank C FC Shankel Stewart W SW Mitchnick Mark M Schmertzler Michael M Bricker Neal S NS
Proceedings of the National Academy of Sciences of the United States of America 20071031 45
Hormonal regulation of salt excretion and water balance by the kidneys is well documented. Before 1961, it was widely believed that the glomerular filtration rate and the steroid hormone aldosterone controlled sodium balance in the body. In 1961, deWardener et al. [de Wardener HE, Mills IH, Clapham WF, Hayter CJ (1961) Clin Sci 21:249-258] showed that when these two variables were controlled, the kidney was still able to increase sodium excretion in response to a salt load. Several lines of evid ...[more]