Ontology highlight
ABSTRACT:
SUBMITTER: Pimanda JE
PROVIDER: S-EPMC2077040 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Pimanda John E JE Ottersbach Katrin K Knezevic Kathy K Kinston Sarah S Chan Wan Y I WY Wilson Nicola K NK Landry Josette-Renée JR Wood Andrew D AD Kolb-Kokocinski Anja A Green Anthony R AR Tannahill David D Lacaud Georges G Kouskoff Valerie V Göttgens Berthold B
Proceedings of the National Academy of Sciences of the United States of America 20071025 45
Conservation of the vertebrate body plan has been attributed to the evolutionary stability of gene-regulatory networks (GRNs). We describe a regulatory circuit made up of Gata2, Fli1, and Scl/Tal1 and their enhancers, Gata2-3, Fli1+12, and Scl+19, that operates during specification of hematopoiesis in the mouse embryo. We show that the Fli1+12 enhancer, like the Gata2-3 and Scl+19 enhancers, targets hematopoietic stem cells (HSCs) and relies on a combination of Ets, Gata, and E-Box motifs. We sh ...[more]