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EWS-FLI1-regulated Core Transcriptional Regulatory Circuit promotes Ewing sarcoma progression

ABSTRACT: We identify and validate an Ewing sarcoma-specific CRC, which is under control of EWS-FLI1. Formed by KLF15, TCF4 and NKX2-2, this CRC apparatus coordinates the gene expression programs in Ewing sarcoma cells. These data advance the understanding of the mechanistic basis of transactional dysregulation in Ewing sarcoma, and provide potential novel therapeutic strategies against this malignancy.

ORGANISM(S): Homo sapiens

PROVIDER: GSE141493 | GEO | 2020/09/29

REPOSITORIES: GEO

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Expression data from the inducible expression of EWS-FLI1 (EF) in embryoid bodies

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