Ontology highlight
ABSTRACT:
SUBMITTER: De Cian A
PROVIDER: S-EPMC2077259 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
De Cian Anne A Cristofari Gael G Reichenbach Patrick P De Lemos Elsa E Monchaud David D Teulade-Fichou Marie-Paule MP Shin-Ya Kazuo K Lacroix Laurent L Lingner Joachim J Mergny Jean-Louis JL
Proceedings of the National Academy of Sciences of the United States of America 20071022 44
Quadruplex ligands are often considered as telomerase inhibitors. Given the fact that some of these molecules are present in the clinical setting, it is important to establish the validity of this assertion. To analyze the effects of these compounds, we used a direct assay with telomerase-enriched extracts. The comparison of potent ligands from various chemical families revealed important differences in terms of effects on telomerase initiation and processivity. Although most quadruplex ligands ...[more]