Ontology highlight
ABSTRACT:
SUBMITTER: Lacroix L
PROVIDER: S-EPMC3045579 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Lacroix Laurent L Séosse Aurélie A Mergny Jean-Louis JL
Nucleic acids research 20101123 4
RNA and DNA guanine-rich sequences can adopt unusual structures called Guanine quadruplexes (G4). A quadruplex-prone RNA sequence is present at the 5'-end of the 451-nt-long RNA component of telomerase, hTERC. As this quadruplex may interfere with P1 helix formation, a key structural element for this RNA, we are seeking molecules that would alter this RNA duplex-quadruplex equilibrium. In this work, we present a fluorescence-based test designed to identify G4 ligands specific for the hTERC G-ric ...[more]